RAF Typhoon jets have operated alongside French aircraft in a coordinated attack on an subterranean weapons facility in Syrian territory used by the IS group, as stated by the UK's MoD.
The location, identified by surveillance, was believed to be containing munitions and bombs, the release indicated, and was situated in mountainous terrain just above the historic site of Palmyra in Syria's central region.
"Our aircraft employed precision-guided Paveway IV munitions to hit a number of entry passages down to the facility... preliminary assessments are that the target was engaged successfully," the ministry announced.
There was no evidence of any civilian casualties in the strike conducted Saturday night and each participating jet made a safe return, the ministry further stated.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - imposed jihadist rule over parts of both Syria and Iraq before its territorial defeat in 2019.
"This operation shows British leadership, and resolve to work closely with our partners, to eliminate any revival of the terrorist group and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief John Healey said.
UK warplanes have performed patrols over Syrian airspace to "forestall any attempted resurgence" of Islamic State subsequent to its military defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I extend gratitude to all the members of our armed forces who took part in this mission for their professionalism and their bravery," the Defence Secretary added. "They were part of thousands of British troops stationed over Christmas and New Year. This operation, to remove terrorist threats who pose a risk to our safety, highlights how British military are always on standby, all year round, ensuring Britain's security at home and powerful internationally."
In December, the American forces executed what it termed a "massive strike" targeting Daesh sites in the country, subsequent to an ambush resulted in the deaths of two US troops and a civilian linguist in the Palmyra area.
The UN says Islamic State still maintains roughly 5-7 thousand fighters in Iraq and Syria.